The body produces white blood cells called lymphocytes to fight infection or foreign substances which have entered the body. Following an organ transplant your body's immune system recognizes the new organ as 'foreign' to you and will try to attack it with lymphocytes. This works by stopping the body from producing these lymphocytes and prevents the attack on the transplanted organ.
Indications for Tacrolimus :
For use after allogeneic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first for use in liver transplantation; this has been extended to include kidney, heart, small bowel, pancreas, lung, trachea, and skin, cornea, and limb transplants. It has also been used in a topical preparation in the treatment of severe atopic dermatitis.
Precautions:
Before taking this drug make sure your doctor or pharmacist knows:
- If you are pregnant, trying for a baby or breast-feeding.
- If you have liver or heart problems.
- If you have recently taken a drug called ciclosporin.
- If you have ever had an allergic reaction to tacrolimus or any other medicine, especially the antibiotics erythromycin, clarithromycin, azithromycin and telithromycin.
Contraindications:
While taking this therapy you should not receive any live vaccines such as:
- Flu vaccine through your nose,
- Measles, mumps
- Rubella, polio by mouth
- BCG (TB vaccine)
- Yellow fever, chicken pox (varicella), typhoid
- Avoid exposure to sunlight and UV light such as tanning machines. Wear protective clothing and use a sunscreen.
Side effects:
- Frequent urination, increased thirst or hunger
- Blurred vision, confusion
- Drowsiness, loss of appetite
- Fruity smell on your breath
- Nausea, vomiting, or stomach pain
Storage:
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
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