Tuesday, 25 March 2014

CellCept (mycophenolate mofetil) is a medicine given by prescription to people who had a kidney, heart or liver transplant. It can help to prevent rejection of the new organ.Your body's immune system can tell that the new heart, liver or kidney is different and tries to reject it. This drug is taken along with other anti-rejection medicines to help control your immune system. They help to keep it from "rejecting" the transplant.

Precautions:
  • People taking high doses of CellCept each day may have a decrease in blood counts, including white blood cells, red blood cells and platelets.
  • Your doctor will do blood tests before you start taking it and during therapy with CellCept to check your blood cell counts.
  • Tell your doctor right away if you have any signs of infection or any unexpected bruising or bleeding, unusual tiredness, lack of energy, dizziness or fainting.
  • Cases of bleeding in the stomach or intestines that required hospitalization have been reported. Early signs of bleeding may include stomach pain, blood in your stool, or dark, sticky stools. Tell your doctor if you have any digestive problems, such as ulcers.
  • People taking this drug should not take live vaccines. Some vaccines may not work as well during treatment with this product.
  • Tell your doctor about all the medicines you are taking including prescription and nonprescription medicines, vitamins and herbal supplements.
Side effects:
  • The most common side effects include: diarrhea, vomiting, pain, stomach area pain, swelling of the lower legs, ankles and feet, and high blood pressure.
  • These are not all of the possible side effects of CellCept. Tell your doctor about any side effect that bothers you or that does not go away.
Storage:
Store at room temperature. Protect from heat, light and moisture. Keep away from reach of children.

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Wednesday, 12 February 2014

Tacrolimus lowers the body's immune system

      Tacrolimus lowers the body's immune system. The immune system helps the body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader.

      The body produces white blood cells called lymphocytes to fight infection or foreign substances which have entered the body. Following an organ transplant your body's immune system recognizes the new organ as 'foreign' to you and will try to attack it with lymphocytes. This works by stopping the body from producing these lymphocytes and prevents the attack on the transplanted organ.

Indications for Tacrolimus :

      For use after allogeneic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first for use in liver transplantation; this has been extended to include kidney, heart, small bowel, pancreas, lung, trachea, and skin, cornea, and limb transplants. It has also been used in a topical preparation in the treatment of severe atopic dermatitis.

Precautions:

Before taking this drug make sure your doctor or pharmacist knows:
  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have liver or heart problems.
  • If you have recently taken a drug called ciclosporin.
  • If you have ever had an allergic reaction to tacrolimus or any other medicine, especially the antibiotics erythromycin, clarithromycin, azithromycin and telithromycin.
Contraindications:

While taking this therapy you should not receive any live vaccines such as:
  • Flu vaccine through your nose,
  • Measles, mumps
  • Rubella, polio by mouth
  • BCG (TB vaccine)
  • Yellow fever, chicken pox (varicella), typhoid
  • Avoid exposure to sunlight and UV light such as tanning machines. Wear protective clothing and use a sunscreen.

Side effects:
  • Frequent urination, increased thirst or hunger
  • Blurred vision, confusion
  • Drowsiness, loss of appetite
  • Fruity smell on your breath
  • Nausea, vomiting, or stomach pain
Storage:
  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

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